Squamous Cell Carcinoma

Actinic Keratosis Features

Actinic keratosis presents with atypical thickening of the epidermis Thickening of the epidermis at the lesion edges is usually focused to the Stratum Corneum layer They can sometimes present with an area of underlying lymphocytic infiltrate from inflammation (*) Actinic keratosis can sometimes be identified by the meshing of the Stratum Corneum and Spinosum layers […]

Squamous Cell Carcinoma in situ Features

A: Epidermal Thickening B: DEJ Alteration C: Hyperkeratotic Layering   In most early SCCIS epidermal thickening is mainly focused to the Stratum Spinosum layer Thickening of the Stratum Corneum layer can also be present Increased prominence and thickness of the DEJ is typical for SCCIS Increased DEJ thickness and increased hyporeflectivity of thickened Stratum Spinosum […]

Squamous Cell Carcinoma Invasive Features

Unlike SCCIS and AKs squamous cell carcinomas tend not to have a distinct or prominent DEJ The focus of the epidermal thickening is from the Stratum Spinosum layer of the epidermis The thickened Stratum Spinosum tends to appear more hyporeflective than normal epidermal keratinocytes owing to the frequency of dysplastic cells Invasion of atypical squamous […]