Actinic keratosis presents with atypical thickening of the epidermis
Thickening of the epidermis at the lesion edges is usually focused to the Stratum Corneum layer
They can sometimes present with an area of underlying lymphocytic infiltrate from inflammation (*)
Actinic keratosis can sometimes be identified by the meshing of the Stratum Corneum and Spinosum layers at their interface opposed to the distinct boundary that is encountered in other squamous derived lesions.
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